HPW-Catalyzed environmentally benign approach to imidazo[1,2-a]pyridines

• Luan A. Martinho and
• Carlos Kleber Z. Andrade

Beilstein J. Org. Chem. 2024, 20, 628–637, doi:10.3762/bjoc.20.55

• -Aminopyridine (1a), 4-nitrobenzaldehyde (2a), and tert-butyl isocyanide (3a) were chosen as model substrates and different conditions were screened (Table 1). Glycerol, a green and sustainable solvent, was tried first, but unfortunately, the expected intense orange solid product 4a was obtained in low yields

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

• Pezhman Shiri,
• Ali Mohammad Amani and
• Thomas Mayer-Gall

Beilstein J. Org. Chem. 2021, 17, 1600–1628, doi:10.3762/bjoc.17.114

• , high yield, the use of dimethyl carbonate as a sustainable solvent, the use of an efficient alternative source of carbon monoxide, and avoiding a pressurized cylinder are some benefits of this protocol (Scheme 35) [59]. A feasible mechanism is illustrated for the synthesis of 1,2,3-triazole-5

Transition-metal-free one-pot synthesis of alkynyl selenides from terminal alkynes under aerobic and sustainable conditions

• Adrián A. Heredia and
• Alicia B. Peñéñory

Beilstein J. Org. Chem. 2017, 13, 910–918, doi:10.3762/bjoc.13.92

• . The reaction does not require selenolate anions as starting materials and proceeds through the in situ formation of diselenides from commercially available potassium selenocyanate. Furthermore, the reaction readily takes place in PEG 200, a sustainable solvent, in short reaction times and under an

Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

• Kirsty L. Wilson,
• Alan R. Kennedy,
• Jane Murray,
• Ben Greatrex,
• Craig Jamieson and
• Allan J. B. Watson

Beilstein J. Org. Chem. 2016, 12, 2005–2011, doi:10.3762/bjoc.12.187

• . Keywords: Cacchi annulation; cross-coupling; heterocycles; Sonogashira; sustainable solvent; Introduction The Sonogashira reaction [1][2] (Scheme 1) is a robust and broadly applicable Pd-catalysed bond-forming process that, alongside the Suzuki–Miyaura reaction [3], has steadily become an indispensible

• , solvent replacement has been designated a key research area with numerous pharmaceutical companies detailing their efforts towards a more sustainable solvent selection as part of their overall sustainability programmes [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Based on its